Mechanism Action Therapeutic Use Olazanpine Ariprpazole Treatment Schizophrenia Biology Essay Essay Example

Mechanism Action Therapeutic Use Olazanpine Ariprpazole Treatment Schizophrenia Biology Essay Essay In pharmacological medicine, drug is a substance used for the bar, diagnosing, remedy and intervention of disease and for the alleviation of symptoms. It could besides heighten physical or mental wellbeing. There are many mental upsets, a province in which an person s mental orientation is disrupted.A Examples of mental upsets include ; A Acute passion, bipolar, schizophrenic disorder, depression, For this peculiar essay I will be speaking about schizophrenic disorder, its symptoms, proposed aetiology and illustrations of the 2nd coevals drug therapies being used to pull off the status. We will write a custom essay sample on Mechanism Action Therapeutic Use Olazanpine Ariprpazole Treatment Schizophrenia Biology Essay specifically for you for only $16.38 $13.9/page Order now We will write a custom essay sample on Mechanism Action Therapeutic Use Olazanpine Ariprpazole Treatment Schizophrenia Biology Essay specifically for you FOR ONLY $16.38 $13.9/page Hire Writer We will write a custom essay sample on Mechanism Action Therapeutic Use Olazanpine Ariprpazole Treatment Schizophrenia Biology Essay specifically for you FOR ONLY $16.38 $13.9/page Hire Writer Schizophrenia is a aggregation of symptoms characterised by idea upsets reflecting a interruption between the cognitive and emotional sides of one s personalityA ( Kathryn L. McCance, 2010 ) .A Schizophrenia is classified into positive and negative symptoms utilizing two systems, viz. ; ICD-10 and DSM-IV ( Horton, Schizophrenia, 2011 ) . Positive symptoms which are unnatural experiences non experienced by other people include Hallucination: Described as a perceptual experience experienced in absence of an external stimulation and characterized largely as auditory with patients proposing that they hear voices speaking to them, about them, commanding them, noticing or an reverberation of their ideas Delusion: False belief that they are under the control of an external influence or their ideas are known to other people i.e. paranoia of the wireless or Television FORMAL THOUGHT DISORDER: A upset of conceptual thought reflecting trouble to understand address and rapid displacement from a subject of capable to another i.e. deficiency of consciousness. New words are besides invented ( neologies ) A ( Horton, Schizophrenia, 2011, pp. 1-2 ) Negative symptoms are normal experiences which are non experienced by schizophrenic patients which include ; SOCIAL WITHDRAWAL/ANHEDONIA: proposing they isolate themselves from the universe LACK OF MOTIVATION: deficiency of involvement in things that antecedently interested them Blunted Consequence: Inability to respond usually to emotional stimulation e.g. when informed of the decease of person they laugh alternatively of sympathising A INSIGHT: schizophrenic disorder patients do non belief anything is incorrect with them or the demand for intervention Nether Activity: Do less and speak less than usually COGNETIVE Deficits: Deficits in attending, memory and job resolution ( Horton, Schizophrenia, 2011, p. 2 ) Epidemiology: An incidence rate of 25 per 100,000 per twelvemonth with Life risk 1 % , common in both sexes but onset earlier in work forces [ average age 28years ] whilst adult females [ 32years ] , common in lower socio-economic groups and urban countries ( Horton, Schizophrenia, 2011, p. 2 ) . Familial epidemiologic surveies indicate it is a heritable upset. Lifetime event hazard indicates 8-10 % for siblings with schizophrenic disorder, one parent with schizophrenia 12-15 % whist with both parents ~40 % . In monozygotic twins the harmony rate was 60 % compared to 10 % in dizygoticA twins and Adoption surveies illustrate that cistrons are more critical compared to environment ( Horton, Schizophrenia, 2011, p. 4 ) . However, it differs from simple familial and Mendelian upsets because it involved several cistrons located on different chromosomesA ( Kathryn L. McCance, 2010 ) .A Therefore, no individual cistron has a major consequence but they include 8p, 13q and 22q ( Horton, Schizophrenia, 2011, p. 4 ) . Pathological surveies have observed the undermentioned grounds in the encephalon of schizophrenic patients and they include hypertrophied ventricles ( ~ 40 % ) , reduced encephalon weight ( ~ 30 % ) , reduced cortical Grey affair ( ~ 4 % ) , unnatural bunch of neurones in the cerebral mantle, little cell organic structures and decreased basal dendrites ( Horton, Schizophrenia, 2011, p. 4 ) . CHEMICAL/ NEUROTRANSMITTER THEORY A DOPAMINE THEORY: Hypothesized as due to over activity of Dopastat in the mesolimbic-mesocortical tract with cell organic structures in the ventral tegmentum of the mesencephalon which undertakings to the amygdaloid nucleus, nucleus accumben, hippocampus, frontal cingulate and entorhinal composite ( Horton, Schizophrenia, 2011, p. 3 ) ( Kathryn L. McCance A ; subdivision editors, 2010 ) . The grounds is supported by looking at the consequence of pep pill in let go ofing Dopastat from dopaine receptors [ subtyped D1, D2, D3, D4 and D5 ] in the encephalon taking to schizophrenic like symptoms ( Horton, Schizophrenia, 2011, p. 3 ) . However, grounds against based on looking at the CSF concentration of HVA found non to be elevated as expected, no alteration in DA receptors in PET scans of drug-free schizophrenics but studies show that increased Numberss of D2 receptors in station mortem sample were due to drug intervention ( Horton, Schizophrenia, 2011, p. 3 ) . In decision, it is hypothesized that hypodopaminergicA transmittal in the dorsal prefrontal cerebral mantle leads to veto symptoms whilstA hyperdopaminergicA transmittal in theA mesolimbicA tracts such as the temporal lobe, A hippocampal, A Amygdala, nucleusA accumbensA and anterior cingulated cerebral mantle leads to positive symptomsA ( Kathryn L. McCance, 2010 ) .A A Glutamate: Evidences indicate an under activity of glutamate transmittal such as reduced cerebrospinal fluid [ CSF ] glutamate, loss of glutamate nerve cells in median temporal parts, addition in certain types of glutamate receptors to counterbalance for lessening in transmittal, glutamate receptor subtype [ NMDA ] antagonist PCP makes schizophrenic symptoms worse ( Horton, Schizophrenia, 2011, p. 3 ) GABA [ gamma-aminobutyric acid ] : Evidence of decreased GABA transmittal due to dorsal prefrontal cerebral mantle alterations/ hypoactivity such as lessened maps ofA GlutamicA acidA DecarboxylaseA needed in biogenesis of GABA lead to the negative symptomsA ( Kathryn L. McCance, 2010 ) .A 5HT [ 5-hydroxytryptamine ] : Evidence show an addition in 5HT [ 5-hydroxytryptamine ] transmittal ( Horton, Schizophrenia, 2011, p. 4 ) . A Environmental FACTORS: These include malnutrition in gestation, grippe in 1st trimester, winter/spring births, bringing complications, caput perimeter at birth and minor physical changes ( Horton, Schizophrenia, 2011, p. 5 ) TREATMENTSA Antipsychotic drugs besides calledA Major tranquilizers to clasp the nerve cell which are effectual in handling acute psychosis and cut downing the hazard of future psychotic episodes ( MedicineNet, 2011 ) .A OlanzapineA andA AripiprazoleA are both 2ndA coevals atypicalA antipsychoticsA which exert their effects on a scope of neurotransmitter receptors i.e. non selective compared to typical 1st coevals neuroleptic which chiefly block D2 receptors. There is a discriminatory action on the DA mesolimbic/mesocortical tract over a nigro-stratial tract but research in carnal surveies is ill-defined ( Horton, Major Tranquillizers, 2011, p. 4 ) . Atypical major tranquilizers which have comparatively high 5HT2A adhering affinity to D2 receptors produce lower EPS [ exptrapyramidial symptoms and depress negative symptoms. Upon entry into the synaptic infinite, the antipsychotic drug must vie with endogenous Dopastat for the receptor. Therefore, curative concentration needed to barricade 50 % o f Dopastat receptors in the presence of dopaminewill be higher than that needed in its absence ( Philip Seeman, 2004 ) . This falls in conformity with the equation C50 % = Ki A? [ 1+D/D2 high ] , where D is the dopamine concentration in the synaptic infinite whilst D2 high is the dissociation invariable of Dopastat at the high-affinity province of the Dopastat D2 receptor ( Philip Seeman, 2004 ) . ARIPRIPAZOLEA Indication: Relieve positive symptoms related to extra Dopastat and negative symptoms towardsA dopaminergicA hypofunction.A It is given at a day-to-day dose scope of 10-30mg but get downing dosage could be 10 to 15mg per twenty-four hours ( Kaplan, 2008 ) .A Mechanism: A AripiprazoleA is aA quinolinoneA derivative. Partial agonist at Dopastat D2 and 5-HT1A receptors upon entry into the synaptic infinite and as an adversary competes with the endogenous serotoninA at 5-HT2 receptors. Described as a Dopastat system stabilizer, in high degrees of Dopastat will move as an adversary ( Horton, Major Tranquillizers, 2011, p. 5 ) such as the mesolimbic tract but non in parts with normal Dopastat degrees such as nigrostratial and tuberoinfundibular tracts. Therefore, a D2 partial agonist is expected to cut down the positive symptoms of schizophrenic disorder without bring forthing motion upsets or elevated lactogenic hormone degrees. In countries where Dopastat activity is low, will move as an agonist to let go of dopamine nerve cells from suppression. The D2 receptor is coupled to inhibitory G-proteins [ Gi ] , which upon agonist binding, dissociates from the receptor to suppress secondary messengerA signallingA mechanisms taking to farther suppr essions. At 5HT1A receptors, aripiprazole besides acts as a partial agonist, hypothesized to correlate with overall efficaciousness against the symptoms of schizophrenic disorder including depression, anxiousness and negative symptoms ( MJ. , 2000 ) .The counter consequence on 5HT2 receptors are believed to be associated with a low liability for extrapyramidial side effects [ EPS ] and good for alleviating negative symptoms by disinhibiting the Dopastat system in the striate body and prefrontal cerebral mantle ( Horton, Major Tranquillizers, 2011, p. 4 ) . Normally, DA nerve cells in the nigrostriatum and prefrontal cerebral mantle are inhibited by serotonin heteroreceptors but hostility of 5HT2 receptors means the release of Dopastat neurones, lower D2 receptor obstruction. It besides does non bring on weight addition or QT protraction ( Horton, Major Tranquillizers, 2011, p. 5 ) . Pharmacokinetics: High soaking up making peak plasma concentrations after 3 to 5 hours, protein binding is 99 % and its half life is approximately 31 to 146 hours doing it suited for one time day-to-day dosing, clearance is affected by age cut downing greatly in the aged. It is extensively metabolised by Cytochrome P450 3A4 and 2D6 enzymes with active metabolite, dehydroaripiprazole ( Burns, 2004 ) . Side EFFECTS: orthostatic hypotension, increased hazard of ictuss, sedation OLANZAPINEhttp: //www.druglib.com/img/Rx/3232.gif ( Druglib, Zyprex ( Olanzapine ) -Description and Clinical Pharmacology, 2006 ) Indication: A negative and positive symptoms ofA schizophrenia, A acute passion with bipolar upset, agitation and psychotic symptoms in dementedness. It is given at a day-to-day dose scope of 5-20mg ( Burns, 2004 ) . Class of drug: Atypical psychotics, ATC Therapeutic CategoryA N05AH: Diazepines, A oxazepinesA andA thiazepines ( PharmGkB, 2010-2011 ) A A Mechanism: Adversary enters the synaptic infinite and competes with the endogenousA ligandsA to suppress IÂ ±-1 adrenoceptors and 5-HT2C which both mediates their actions by association with G proteins [ Gq/11 ] that activate a phosphatidylinositol- Ca 2nd courier system whilst at 5-HT2A promotes dopamine release ( Druglib, 2007 ) . In the nigrostriatal tract increased DA reduces EPS and tardive dyskinesia ( Yogesh Dwivedi, 2005 ) but in the mesocortical tract, increased DA release may better negative symptoms, that neuroleptic induced shortage syndrome ( Voruganti L, 2004 ) . OlanzapineA does non look to barricade Dopastat within theA tubero-infundibularA piece of land, explicating the lower incidence ofA hyperprolactinemiaA than with typical antipsychotic agents but alternatively blocks 5-HT2A receptors ( Druglib, 2007 ) . As an adversary of D1 Gs-coupled proteins receptor it prevents activation of Adenylyl cyclase and DARPP-32 ( dopamine andA cAMPA regulatedA phosphoproteinA of 32A kD ) .A Dopamine adhering activates the 2nd messengerA camp to trip ProteinA KinaseA A ( PKA ) which phosphorylatesA DARPP proteins atA ThreonineA residue 34A to suppress phosphataseA protein ( PP1 ) leting PKA to hold a longer active life and overall, A enhanceA the nerve cell s sensitiveness to dopamine signalling. In contrast, dopamine adhering to D2 receptors has an opposite consequence: the 2nd messengerA phosphorylatesA DARPPA on Thr75, doing it to move as a proteinA kinaseA inhibitor andA decrease the nerve cell s sensitiveness to signalling. The D2 and D4 receptor are coupled to inhibitory G-proteins, which dissociate from the receptor on agonist binding and inhibit secondary messengerA signallingA mechanisms doing farther signalling suppression ( Greengard, 2011 ) . Antagonist adhering inhibits this procedure, ensu ing in cell depolarisation.A They besides cause Dopastat to cut down DARPP-32A phosphorylation ( Sarah M. Clinton, 2005 ) . A In add-on, it antagonises histamine H1, A MuscarinicA M1 [ mediate their actions through G-protein-Gq/11 [ in some cases Gs and Gi ] .A Therefore, olanzapine can be seen to hold multiple receptors activities. Side EFFECTS: CNS depression which is due to it counter effects on H1 receptors, orthostatic hypotension, automatic tachycardia and rhinal congestion due to alpha1 suppression whilst blurred vision and urine keeping due to M1 suppression, weight addition, increased QT intervals observed in ECG and increased hazard of shot in dementia aged patients ( Horton, Major Tranquillizers, 2011, p. 4 ) Pharmacokinetics: its half life is 20-70 hours, plasma clearance is 12 to 47L/h and its protein binding is 93 % . It is eliminated extensively by first base on balls metamorphosis, with about 40 % of the dose metabolized before making the systemic circulation by enzymes ; Cytochrome P450 2D6 and 1A2 with no active metabolite ( Burns, 2004 ) . Decision Olanzapine and aripiprazole are therapeutically used orally to handle schizophrenic disorder and have different mechanisms of action. Olanzapine is a multireceptor adversary, suppressing M1, H1, IÂ ±-1, D1, D2, D4 and 5-HT2A/2C receptors whilst Aripiprazole is a breakthrough neuroleptic with partial agonist activity on 5-HT1A and D2 receptors leting it to jump its actions and an adversary of 5-HT2 receptors. They are both used to alleviate positive and negative psychotic symptoms presented in schizophrenic disorder and both have a comparatively high 5HT2A adhering affinity to D2 receptors produce lower EPS [ exptrapyramidial symptoms ] and depress negative symptoms. More so, they portion side effects such as orthostatic hypotension, . Therefore, close monitoring of patients is necessary to guarantee they acquire the best out of their interventions with control over their symptoms and possible drug induced side effects. NICE guidelines published 2002, it is recommended that unwritte n untypical antipsychotic drus are considered in the pick of first-line interventions for persons with freshly diagnosed schizophrenic disorder or considered as intervention options for single presently having classical antipsychotic drugs who, despite equal symptom control, are sing unacceptable side effects and for those in backsliding who have been antecedently experienced unsatisfactory direction or unacceptable side effects ( Horton, 2011 ) . hypertext transfer protocol: //books.google.co.uk/books? id=ubG51n2NgfwC A ; pg=PA546 A ; lpg=PA546 A ; dq=aripiprazole+schizophrenia+mechanism A ; source=bl A ; ots=tm_B5jFcxW A ; sig=KkMB7rniRAyPMTbXjK3CQl8xXPA A ; hl=en A ; ei=gfKUTYCoMIeohAfL6rT2CA A ; sa=X A ; oi=book_result A ; ct=result A ; resnum=9 A ; ved=0CFoQ6AEwCDgK # v=onepage A ; q=aripiprazole % 20schizophrenia % 20mechanism A ; f=false hypertext transfer protocol: //books.google.co.uk/books? id=WuA4LsWXXWEC A ; pg=PA510 A ; lpg=PA510 A ; dq=olanzapine+inhibition+of+5HT2+receptors A ; source=bl A ; ots=ijCtcFYFJk A ; sig=IdYjVggzCLVrGihyl435NUPEjKs A ; hl=en A ; ei=3uqZTcjlO9G5hAesy53wCA A ; sa=X A ; oi=book_result A ; ct=result A ; resnum=5 A ; ved=0CCsQ6AEwBDgK # v=onepage A ; q A ; f=false

A Little Fox Never Hurt Anyone

A Little Fox Never Hurt Anyone A Little Fox Never Hurt Anyone A Little Fox Never Hurt Anyone By Kate Evans We all know that good looking women are described as foxy. But foxes, with their rusty color and reputation for craftiness, can be used in many other colorful, unique, and descriptive expressions. For example, A foxs sleep is when one feigns indifference while keeping a close eye on someone. A wise fox will never rob his neighbors hen-roost, meaning a thief should steal from people far from home so as not to get caught. Theres my personal favorite, I gave him a flap with a fox-tail, which means that I made a fool of someone. To set a fox to keep the geese would be someone who trusts those who should clearly not be trusted with important tasks. If its a case of the fox and the grapes, then someone really wants something, cant obtain it, so they pretend they never wanted it in the first place. And of course, theres the often relevant when a fox preaches, take care of your geese. So, go off and flap someone with a fox-tail or just try and work one of these expressions into your next short story! Apollo Theater, Ms. Brown had the limo pull to a stop before a 100-foot-long Chyna Doll billboard, featuring a very foxy Foxy, clad only in a blue feather bikini. (www.nytimes.com) Want to improve your English in five minutes a day? Get a subscription and start receiving our writing tips and exercises daily! Keep learning! Browse the Expressions category, check our popular posts, or choose a related post below:45 Synonyms for â€Å"Food†Awoken or Awakened?Ulterior and Alterior

Discuss the role of university research in innovation in the knowledge Essay

Discuss the role of university research in innovation in the knowledge economy - Essay Example Basic research is a study aimed at greater understanding of the phenomenon under study. The main objective of applied research is to answer and address real-world challenges. It includes systematic analysis of practical part of science. It deals with practical challenges and uses experimental methodologies to solve them. Research and innovation is linked to social and economic development of a country. In Europe, most projects contribute to minimizing regional disparities by improving innovation and research potential. Research has been growing since the end of Second World War. Most firms participate in applied research because it can be marketed easily. Most industries can collaborate with universities specialized in applied technology. Mechanism of Research Governments have made policies to structure innovations and research in the universities. They ensure that there is a return on public investments in terms of social prosperity and economic growth (Rothaermel & David 2008, p.17 ). The role of different actors in the field, their abilities to conduct the research currently are on transnational research networks. Information on research and innovation is necessary for policymakers so that they may be able to see how they can help the universities to promote their innovation and research in the market.... Government support is not enough in most institutions. In most cases, universities collaborate with industries in conducting research. Universities have people, units, and functions, which are involved in partnership actions that have an effect on technological and economic development. They do this by licensing and spin-offs. Universities differ in the way they organize their programs or activities so as to foster innovation. Research institutions, majorly in the United States, are more concerned about their societies in the recent past. This is because they represent the inner resources of knowledge in those societies. Competency of individuals, knowledge and skills and their application has improved significantly in the economy where these individuals work. Most countries focus on the development, application, preservation, and discovery of all forms of knowledge and skills. These are the humanistic, scientific, and social knowledge. They therefore assist publicly and privately fu nded universities. The institutions then appreciate these contributions by appropriately contributing to the development in economy. They enhance knowledge linking activities, which improve technology commercialization, enhance workers’ competency, and assist community and organizational change and increase competency of professionals (Chen, K & Kenney, M 2007, p 1056). They also provide social, economic, and cultural organizational analyses to train and educate individuals and to bring individuals and groups concerned about rational, informed discourse on matters of common concern (Gebauer et al 2005, p.650). The capabilities of these universities are vest in many places, not only schools of business and

Autism and Autism Spectrum Disorder and different teaching methods in Research Proposal

Autism and Autism Spectrum Disorder and different teaching methods in the classroom - Research Proposal Example It is said great scientists Newton and Einstein too had Autism in some form or other. Only it has been recognized of late and meriting the attention of the social scientists to ease the ASD affected individuals out of the so-called disorder so that they can scale newer heights. Autism is a developmental problem found early in childhood that results in verbal, non-verbal communication or social interaction disability. Usually this disability becomes evident before the age of three and has a bearing upon educational performance when the child grows older. Autism is also known as autism spectrum disorder, pervasive development disorder (PDD), PDD- not otherwise specified (PDD-NOS), atypical autism, and Asperger’s Syndrome. Autism Spectrum Disorders (ASD) occurring early in life will last for the rest of one’s life. It is not a single disorder but a syndrome of collection of characteristics in growing children. Though ASD is found in both males and females, the incidence is more in males. It is severe and pervasive when it affects almost all the faculties of the individual even though he may be very intelligent or high functioning. ASD also occurs when the individual has cognitive impairment also known as mental retardation or mental impairment. ASD can also occur due to neurobiological reasons affecting the physical brain or chemistry of the brain. When the individual is not able to communicate by using speech or language or when his speech is delayed or quality of communication or verbal skills are affected, he is deeme d to have ASD. In some cases, the individual cannot display unspoken language such as gestures, facial expressions. ASD also makes the individual unable to understand what others say and respond to them or their non-verbal movements. The individual will have difficulty maintaining friendship and social contact regardless of age even though he may want to keep the relationships. He will be sensitive to touch,

Media Representation of Violent Crimes | Race

Media Representation of Violent Crimes | Race The thesis of the paper is, the media representation of violent crimes by African Americans. It has indeed been proven that the media portrays a very negative image on violent crimes as perpetrated by black Americans and this to a large extent ÂÂ  impacts on the law, regulations, and public perceptions on the violent crimes. For instance, a violent crime such as rape has been painted as a grim reality that all of us need to be aware. This has had the effect of even influencing the way law makers perceive rape. It has eventually led to stringent laws being developed to deal with the crime by the blacks. The most notable law in the US history was the one restricting the way in which the sex offender moves through the sex offenders restrictions Act. This paper will succinctly focus on the various media perceptions about the violent crimes and especially the way the media represents violent crimes thus influencing the public perception of the same. The result of the media representation of violent crime by black Americans has been more strict measures being taken that is aimed at curbing the propagation of such crime. Previously as noted, such crimes were often silent and thus the public did not know much about the violent crimes. However, due to the media representation of such violent crimes, crimes such as assault, wife battery have now become more pronounced more than ever. It has therefore become clearly known that the violent crimes are treated with more weight as a result of increased knowledge by the public especially of the violent crimes (Lind, 2004). The media has often been faulted for propagating violence in many forms. The violence that is portrayed by the media actually encourages the vice to continue instead of helping to educate the public in order to avert future problems. It was revealed that most of the news that sells in the media and attracts much attention is news pertaining to violent crimes by the black Americans. We would often turn the volume of our television or radio sets up in order to listen to some shoot out news in which a gangster or police officer was killed or more so to listen to testimonies by witnesses in a rape or robbery case. The body of this paper shall consider the impacts of the media representation on violent crimes by the black Americans. Indeed, criminology theories are often contemporary theories and not standalone theories as perceived by most scholars (Croteau Hoynes, 2000). The theories help to explain the rationale behind what most criminology researchers put forth. In this paper, we shall explain how the media representation of violent crimes impacts on the law and generally on the US regulations in light of the classical criminology theory. Several researchers have explored the media representation of various phenomena, with very few suggesting that the media rarely imparts positive impact on the law and public perceptions on violent crimes. Furthermore, it is imperative to note that the media indeed influences different aspects of the law by painting a stern picture of the violent crimes through emphasizing on the consequences of such crimes and the reality in terms of victims that are left after the perpetration of such violent crime. We shall first begin by looking at the positive impact that the media has on its representation of violent crimes to the society at large. Firstly, it is important to note that most of the violent crimes go against the societal values and core beliefs. This has indeed made the media to point out the reality behind such violent crimes. It is often common to see the media emphasizing on the effects of such violent crimes such as rape. Sometimes, the media even uses real victims to succinctly convey the message. This has left several impacts as insinuated by several researchers. A lot of research has been done to determine the spate of media influence on the violent crimes to the society. Critics suggest that the media has made the publics perception about violent crimes by the black Americans to change. This has observably changed for the worse. Consequently, research has shown that violent crimes could be effectively be dealt with at a higher level by the law enforcement agencies. What is most important is the awareness by the general public. The media therefore plays a pertinent role in fostering this. Maguire, Morgan and Reiner (2007) reveal that the picture painted by the media on violent crimes by black Americans such as rape has made the law makers to realize how serious the violent crime can affect the society. In particular, law makers have become more aware of the factors that actually lead to the propagation of violent crimes so that they may effectively pass laws that will ensure that the activities that lead to the violent crime or at least contribute to the violent crime are kept in check. For instance, rape in the media was portrayed as emanating from the activities of idle boys and the youth who apparently did not have anything to do. This in turn made the law makers to seek ways of preoccupying the youth in a more constructive manner. Therefore, the youth development projects were formed to take care of the needs of the youth. Apparently, the youth in California were found to be engaged in various activities (Greer, 2003). Some of these activities were not so construc tive as such. Therefore, the law makers formulated laws that effectively ensured that the youth were well occupied. This therefore meant that the youth could be engaged in educational as well as community activities. Consequently, the media representation of the violent crimes made it easier for the public to perceive violent crime as an emerging crime that was previously hidden under the pillow. This therefore apparently enabled crimes such as assault and domestic violence to emerge and become topical issue in the media as well as in the public forum. The result of this therefore was that the public became more aware of the effects of violent crime, specifically, domestic violence and assault as well as rape. Thus, the media has been extremely successful in exposing such crimes to the public knowledge. The public has responded by being more vigil in terms of fighting the crime through community oriented initiatives. The media in conjunction with the police bring to the attention of the public certain crimes that they would have otherwise been ignorant of. The media continues to be ardent in exposing criminal activities and syndicates. The most recent syndicate to be exposed was that of track it which apparently fleeced unsuspecting citizen of millions of dollars. Apparently some of the renowned black Americans were connected to this syndicate which was accused of defrauding the public of their innocently earned money. This way, the media ensures that unscrupulous business entities are busted and their licenses ceased. Lind (2004) suggests that the spate of crime by the Black American is on the rise and if nothing is done to address the root cause, then it is likely that this could escalate beyond repair. The society at large subsequently instigated steps that were meant to curb the growing trends in the violent crimes. The trends of such violent crimes can thus be monitored and steps taken by the law makers and the public to mitigate it. This has therefore had the positive effect of reducing the incidences of violent crime within the society setting. Stenson and Sullivan (2001) insinuate that the media alert on violent crime has helped the public to specifically improve their response to such crimes thus reducing the occurrences of such crimes. In particular, the public has become more receptive in helping the police to monitor such kinds of crime through the community oriented policing modules. In her book, Lind (2004) reveals that the media indeed portrays race as a contributory factor towards the violence as seen in most of the scenes of violence. The black Americans are particularly faulted for being boisterous in terms of their propensity to propagate violent crimes. In the United States, nearly half of those individuals who are incarcerated are black Americans. This indicates a worrying trend that must be mitigated. The media also revealed that the state of Texas had been coarsely affected by the increase in the number of inmates who had been incarcerated by the federal government. The federal government on the other hand has the relevant statistics necessary to formulate the necessary measures aimed at averting the vice of violent crimes. Media is the mouthpiece of the society. The society has come to believe the media in most of the aspects pertaining to the society in general. Therefore, it is the onus of the media to ensure that they consistently inform the public of the various happening and to subsequently effectively warn the public of a growing trend. The public is therefore receptive of such happenings that will affect its perceptions as propagated by the media. More often, the media simply According to Davies, Francis and Greer (2007), crime occurs where the benefits outweigh the costs. This is the definition of the classical theory of criminology. The classical theory of criminology therefore goes ahead to state that when people are after self interest, with the lack of presence of punishment that is tangible or even intangible, crime occurs. Therefore what this means is that the violent crime occurs as a result of lack of knowledge by the general public. This also means that the media serves as an important vessel in mitigating crime by the blacks through effectively monitoring crime prevalence. Media has been very successful due to its ability to reach multitudes of people at the same time thus ensuring that information is conveyed to masses. The law makers also serve to formulate laws that ensure violent crime by black Americans is kept in check (Miller, 2003). This could not be possible without the contribution of the media in highlighting the areas of violent cri me that the law makers need to focus on. Moreover, this will have a ripple effect in ensuring that the violent crime does not continue and is effectively put under check. The classical theory also states that crime, and violent crime for that matter is a free will and upon an individuals choice. The people who propagate crime are therefore people of sane mind, body and spirit. Therefore, what this means is that violent crime by the black Americans has indeed been a matter of choice. According to Muncie and Wilson (2004) issues regarding choice can only be eliminated through publicity and increasing awareness. This as earlier mentioned can best be done by the media. The media has for ages painted a grim picture of violent crime and been against it in totality. This has therefore meant that the violent crime incidences have been shunned by the society in general and thus led to a decline in cases involving violent crime. On the other hand, the media has negative impact in terms of the image that it paints in relation to the violent crime on the society as well as the impacts that it has had on the laws and regulations. Greer (2003) notes that the media has overblown the issue of violent crime beyond proportion thus making it difficult for the determination of the true magnitude of the violent crime and the extent to which it should be shunned The consequences of this have been thorough in terms of influencing the way law makers perceive violent crime. It is also true according to the classical theory of criminology that the violent crime by black Americans is the brain child of a society that lacks direction. This is indeed a wakeup call for the law makers and the relevant administrators to take up the challenge and rise up to the occasion as pertains to ensuring that the perpetrators of violent crime are dealt with. Maguire, Morgan and Reiner (2007) concur by suggesting further that the law makers have accorded strict punishment to some of the violent crimes such as assault thus putting the perpetrators who may have acted under self defense to thorough capital punishment. Similarly, the law makers have been very mean in terms of passing amendments meant to reduce the punishment accorded to the perpetrators. Critics suggest that the best form of punishment that would be suitable for the perpetrators of violent crimes would be serving several years behind bars and then community service for a couple of years (Davies, Francis Greer, 2007). The media representation of violent crime by blacks Americans has therefore left very stern action taken by the law makers. Furthermore, the public at large have been left with a very bad perception. Greer (2003) suggests that the public now view most of the violent crimes by the black Americans as gross. This has made the public to take very stern action while dealing with the perpetrators of such violent crime such as rape. The public has therefore become autonomous in terms of judging a person suspected to have perpetrated the violent crime and subsequently played the part of the court or judicial system. This has made the public to take law into their own hands and set ablaze or even brutally killed the perpetrators. The classical theory of criminology further supports the fact that violent crime is caused by an individuals volition. This volition should be turned for the good of the individual through encouraging good behavior within the community and thus effectively rehabilitating a violent crimes perpetrator. Stenson and Sullivan (2001) suggest that the media has effectively denied the perpetrators of violent crime the chance to change and be part of the society. This theory further supports a no-crime environment through solving crime from its roots. Therefore, the law enforcement agencies will have a very smooth ride due to the implementation of these theories. The other important negative impact of the media representation of violent crime by the black Americans has been that individual especially the teenagers who are apparently below the age of majority have been exposed to violence at a tender age. The media has therefore succeeded in changing the perception of such age groups of violent crimes since they view this as a normal happening and therefore they grow up knowing that violent crime by the black Americans is part of the society. Muncie and Wilson (2004) suggests that it is usually very difficult to change such perception. In fact, the teenagers perception of violent crimes by the black Americans is so grim such that some of them even aspire to perform the same acts that the media condemns. Too much exposure to violent scenes is not good for the development of the teenagers. Recently, there has been a huge outcry on how the media portrays violent crimes by the black Americans without discretion to the populace. It is important to note that the populace consists of diverse ages. It is ethically wrong at least according to Greer (2003) from the media to show violent crimes to the youth. It can therefore be concluded that the classical theory is indeed the most effective in explaining the media representation of violent crime by the black Americans and advancing the ways that we can deal with such perception and representation to develop more positive laws and regulation as pertains to curbing the incidences of violent crimes. Therefore, the media has been more beneficial more than detrimental to the general public through the various sensitization programs that it advocates for in totality. Crime rates by the black Americans have been effectively reduced due to the proactive nature of the media towards informing the public and the police together with other law enforcement agencies of the impending violent crimes and their consequences.

Valentine’s Day

With Valentine's Day approaching, I plan some cheer in the lives of college students. I prepare hundreds of love poems by the famous and the infamous on slips of paper to be tossed in a basket and passed around the classroom. And we share poems in April during National Poetry Month. Last December when we read â€Å"A Christmas Memory† by Truman Capote, I noted that not one student in class had ever tasted fruitcake. I made some and brought it in for a taste test (ingredient list on BB to avoid any allergies). My students always know the homework and what is expected, but I like to bring in the unexpected. They know that for me â€Å"education should be fun BUT education is never a joke.† I grew up in dreadful Appalachian poverty, the only one in a large extended family to attend college. My students know the story. If a person works hard, most of life works out and brings rewards. I demand that they work hard. I have been teaching for almost 40 years. I am not shy about calling a student into my office and using the â€Å"metaphorical stick† to say: you are brilliant. Why are you so casual about your studies? I receive emails or letters from students to let me know how life worked out for them. One of the young men whom I had reprimanded in my office for taking his studies too frivolously sent a note that he had just received his PH D and had accepted a position as a Superintendent of Schools in Connecticut. I have served on every committee and volunteer to mentor young faculty. I understand that at my age, they must say: she is still excited to enter the classroom after all these years. What is the secret? I have presented at both national and international conferences. About five years ago I began to question the value of our curriculum in developmental education. That led to much research, a chance meeting with Peter Adams of Community College of Baltimore who became my mentor. I knew that our administration and Trustees would not consider class sizes of eight (Peter's recommendation and practice) so I devised a triad system. Two classes of ENGL 101 (nine developmental students nestled into the 20 in each section). The two nines join later in the support class of eighteen. We have had phenomenal results in both retention and graduation. When the need arose recently for an Honors program, I stepped up to get that curriculum going. Students stop by my office to chat or to ask that I listen. When a student enters, I place everything aside and am â€Å"in that moment.† I have been voted Faculty of the Year twice by students and was presented with the Lindback Teaching Excellence Award. I look forward to every day with my students and with my colleagues in the community college.

Office Automation and Group Collaboration Software Essay

As the business becomes smaller and smaller due to globalization making the business environment more dynamic and competitive, organizations of today are fast realizing the importance of information as an critical asset to successes. This in turn increases the importance of automated soft wares and group collaborations systems, which make information management and use more efficient and effective. This articles explores how Office Automation and group collaboration Systems like Groove are increasingly applied to manual business functions in a network of computers in an organization, which help in business communications, writing reports, saving information and statistics, and group of people working on a project from different location and same or different time frames, all integrated in automated software which saves both time and money increasing the work productivity of the employees. An office automation system heavily relies on a network of workstations in order to create an uninterrupted and fast approach to sending and receiving information in a timely fashion. This can be a local Area Network or LAN for local destinations, for example a network of computers with in a building etc or it can also spread across countries through a Wide Area Network (WAN), which can also be use send instant messages across . this network also provides a secures work space for individual workstations to share and work on documents using groove as a group collaboration software. The functions of an Office Automation System include electronic publishing soft wares which allow users to create documents, edit them as and when requires, insert tables, charts or any other graphics, electronically store important documents and even print them in the form of memos, periodic or ad hoc reports and letters, all these functions are performed by word processing soft wares where as a desktop publishing software can also be used for professional documents for examples brochure, and by making use of available templates for magazines etc Then we have Electronic communication soft wares, as a part of the Office Automation System used for face to face communication with executives in other cities or countries through desktop video conferencing incase of two employees communicating with each other, or electronic collaboration systems which allow different work groups to communicate face to face with each other and work on projects via a network of computers regardless of the geographical location. Another important branch of Office Automation Systems is Telecommuting which now makes It possible for employees to work from home or distant locations avoiding long distance travelling, traffic by connecting to the organization’s local or wide area network. One of the greater advantages of telecommuting is that it allows organization to use the untapped pool of the handicapped people and single parents who for reasons of their own cannot come to the work place. Other advantages of Office Automation Systems is that it also incorporates image processing and presentation and multimedia soft wares like PowerPoint, SPC Harvard Graphics etc which allow the users to edit and integrate both image and texts, videos etc and share it using work collaboration systems. Another important advantage of group collaboration soft wares in this era of globalization is that it allows work groups to work on and share information and coordinate activities at same place same time or different place, different times ensuring a smooth work flow through out the wide spread organization. Although Office automation and group collaboration software make work life a lot easier for us, yet one has to be cautious about the limitations they offer along with the advantages. The soft wares can be used for personnel use unrelated to work. For example instant messaging can be used to discuss topics other than work which wastes both time and office resources. As far as group ware is concerned they can be expensive, may require extensive training, mat not support the rapid changes in technology and due to the availability of company related information with different people at different places it can also lead to a leak in critical information. Therefore, after realizing the importance of automates software and group collaborative system which without any doubt increase work productivity and make coordination of various work activities very easy for us, one must be aware that it does come with certain limitations for which caution should be exercised. After all, information is a critical asset which needs proper management.